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期刊论文 27

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IEEE80216 1

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交通工程 1

交通规划 1

信息中心网络，物联网，节点监测，访问控制 1

修正路由 1

决策树；多类不平衡学习；节点划分准则；海林格距离；一对多技术 1

分布式存储系统；数据可靠性与可用性；异或类纠删码；单节点失效；数据恢复 1

双库协同机制 1

图学习；半监督学习；节点分类；注意力机制 1

地图匹配 1

多跳双向认证 1

宫内节育器；盆腔炎性疾病；细菌生物膜；SEM 1

左炔诺孕酮宫内系统；胰岛素样生长因子；盆腔炎 1

控制器局域网；发送错误计数器；发送错误计数器值估计；贝叶斯网络；脱离总线时间 1

数据子类结构 1

本原数据库 1

本原知识库 1

热电能；能量收集；最大功率点跟踪（MPPT）控制；自供电系统；传感器节点 1

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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 96-100 doi: 10.1007/s11684-014-0316-4

摘要：

Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this study, 80 patients were divided into groups A and B. Group A consisted of 30 patients who underwent PAN+ pelvic lymph node (PLN) dissection, whereas group B consisted of 50 patients who only underwent PLN dissection. Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conducted. Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive for PAN, three cases for PLN, and nine cases for both PAN and PLN. In group B, 13 cases were positive for lymph node metastasis. Our study suggested that the metastatic rate of lymph node is 40.0%. Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological type both in groups A and B (P<0.05). In groups A and B, the three-year survival rates were 77.9% and 69.0%, and the five-year survival rates were 46.7% and 39.2%, respectively. However, the difference was not statistically significant (P>0.05). The three-year survival rates of PLN metastasis in groups A and B were 68.5% and 41.4%, and the five-year survival rates were 49.7% and 26.4%, respectively. Furthermore, PLN-positive patients who cleared PAN had significantly higher survival rate (P=0.044). In group A, the three-year survival rates of positive and negative lymph nodes were 43.5% and 72.7%, and the five-year survival rates were 27.2% and 58.5%, respectively. The difference was statistically significant (P=0.048). Cox model analysis of single factor suggested that lymph node status affected the survival rate (P<0.01), which was the death risk factor. Consequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, which has an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary.

关键词： ovarian cancer     para-aortic lymph node     pelvic lymph node    

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Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

《医学前沿（英文）》 2009年 第3卷 第1期   页码 13-19 doi: 10.1007/s11684-009-0016-7

摘要： Lymphography is often used for the diagnosis of lymphatic metastasis in oncology. Determination of lymphatic metastasis is extremely important for accurate cancer staging, which may directly guide the clinical therapeutic scheme. In recent years, the technology of lymphography has developed rapidly on the basis of traditional lymphography, with the appearance of computed tomography (CT) lymphography, nuclear magnetic resonance (MR) lymphography, contrast-enhanced lymphosonography, and so on; the diagnostic accuracy has also been improved. The imaging principles and methods of these various technologies of lymphography are reviewed in this paper, and their applications and significance in oncology are also discussed in detail.

关键词： lymphography     lymphatic metastasis     sentinel lymph node biopsy    

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The value of ultrasound elastography in differential diagnosis of superficial lymph nodes

Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 368-374 doi: 10.1007/s11684-009-0063-0

摘要： The study evaluated the value of ultrasound elastography in differentiating the benign and malignant superficial lymph nodes. A total of 112 subjects, including 82 patients with enlarged lymph nodes and 30 healthy volunteers, were recruited. All the subjects were examined by B-mode ultrasonography, power Doppler ultrasonography and elastography. Most of the patients were histopathologically confirmed by needle aspiration cytology and some patients were diagnosed by clinical data combined with follow-up findings. The sensitivity, specificity and accuracy of B-mode ultrasonography were 59.8%, 76.5% and 67.1%, those of the blood flow classification by power Doppler ultrasonography 77.0%, 82.3% and 79.4% and those of elastographic classification 74.7%, 97.1% and 84.5%, respectively. The elasticity of the lymph nodes was quantitatively measured and defined as stiffness value. When the stiffness value of 2.395 was taken as the cutoff point, the sensitivity and specificity of elastography were 78.41% and 98.51%, and the Youden index reached the highest, with the value being 0.7692. The stiffness values of two indeterminate benign lymph nodes, the elastrographic findings of which were rated as patterns 2 and 3, were below the cutoff point. The elastographic findings of 10 malignant lymph nodes were also classified as pattern 2 or 3. Only one of them had the stiffness values below the cutoff point. It was concluded that ultrasound elastography is a novel, noninvasive and convenient tool for the differentiation of the nature of the superficial lymph nodes in clinical practice.

关键词： ultrasound elastography     lymph node     power Doppler sonography    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 106-112 doi: 10.1007/s11684-014-0307-5

摘要：

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma (SCC) IA--IIA, and SCC IIB--IIIB (4.3%, 44%, and 88.9%, respectively). The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated β-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.

关键词： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

《医学前沿（英文）》 2023年 第17卷 第1期   页码 93-104 doi: 10.1007/s11684-021-0892-z

摘要： We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

关键词： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Spatial embedded reinforcement of 20-node block element for analysis PC bridges

LONG Peiheng, DU Xianting, CHEN Weizhen

《结构与土木工程前沿（英文）》 2008年 第2卷 第3期   页码 274-280 doi: 10.1007/s11709-008-0039-1

摘要： The formula for the contribution of prestressed reinforcement on embedded reinforcement element is derived according to the mechanical behavior of PC bridges and the foundational principle of finite element method. Mechanical concept is definite and examples validate the calculation results. Reinforcement element model allows generating a finite element mesh without taking into consideration the layout of reinforcements. Furthermore, the prestressing tendon may pass through the concrete elements in an arbitrary manner. It is an effective approach that the no-node loads are diverted from the tendons to the adjacent concrete elements. A useful arithmetic analysis of the spatial curved tendon PC Bridges is provided.

关键词： arithmetic analysis     calculation     prestressed reinforcement     mechanical     arbitrary    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

《医学前沿（英文）》 2021年 第15卷 第4期   页码 621-628 doi: 10.1007/s11684-020-0738-0

摘要： Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

关键词： early breast cancer     21-gene assay     recurrence score     prognosis    

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基于虚拟节点道路网络模型的设计及实现

朱庄生,王庆,万德钧

《中国工程科学》 2009年 第11卷 第8期   页码 83-87

摘要：

利用传统的基于节点连接的道路网络模型来表达真实世界中的道路网络，其存在的缺陷越来越突出，大大降低了导航系统的鲁棒性。为了消除这些缺陷，首次提出一个新的道路网络模型，即基于虚拟节点连接的道路网络模型，其虚拟节点是汇交路段的各个端点所围成的区域，具有真实道路路口的形状，与传统模型相比，该模型更能表达真实世界道路网络中的交通流，所以它能更好地满足地图匹配理论要求。另外，该模型能很好的表达真实道路路口参数，所以它在交通规划，交通管理和交通流模拟中都有着十分广阔的应用前景。

关键词： 交通工程     虚拟节点     道路网络模型     地图匹配     交通规划    

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信息中心物联网节点状态监测技术研究

崔立群,伍军

《中国工程科学》 2020年 第22卷 第6期   页码 121-127 doi: 10.15302/J-SSCAE-2020.06.016

摘要：

为了管理信息中心物联网（IC-IoT）不断变化的网络状态信息，本文针对信息中心物联网提出一种节点状态监测方案，以更好适应未来网络的发展。首先提出一种新的管理信息库结构用于记录各种网络节点状态信息，采用信息中心网络（ICN）的命名格式，以网络节点状态内容本身为中心。在此架构上采用跟踪路由方法，结合基于数据块重要性的自适应数据放置策略来获得所需的网络状态信息，提高网络节点状态信息检索效率，同时设计了安全防护机制来达到保证数据机密性与对管理用户进行访问控制的目的。搭建网络仿真测试环境评估了上述跟踪路由机制、自适应数据放置策略、访问控制安全防护带来的时延影响，仿真结果表明此方案能够有效地提高数据获取效率，访问控制模型提供了数据机密性和其他安全性功能，仅附加了少量的计算成本。

关键词： 信息中心网络，物联网，节点监测，访问控制    

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Simulation of cohesive crack growth by a variable-node XFEM

Weihua FANG, Jiangfei WU, Tiantang YU, Thanh-Tung NGUYEN, Tinh Quoc BUI

《结构与土木工程前沿（英文）》 2020年 第14卷 第1期   页码 215-228 doi: 10.1007/s11709-019-0595-6

摘要： A new computational approach that combines the extended finite element method associated with variable-node elements and cohesive zone model is developed. By using a new enriched technique based on sign function, the proposed model using 4-node quadrilateral elements can eliminate the blending element problem. It also allows modeling the equal stresses at both sides of the crack in the crack-tip as assumed in the cohesive model, and is able to simulate the arbitrary crack-tip location. The multiscale mesh technique associated with variable-node elements and the arc-length method further improve the efficiency of the developed approach. The performance and accuracy of the present approach are illustrated through numerical experiments considering both mode-I and mixed-mode fracture in concrete.

关键词： extended finite element method     cohesive zone model     sign function     crack propagation    

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左炔诺孕酮宫内释放系统对胰岛素样生长因子-1的影响与预防盆腔炎的相关性研究

吴晓杰,刘霞,陶跃平,王洁

《中国工程科学》 2015年 第17卷 第6期   页码 4-7

摘要：

目的：研究左炔诺孕酮宫内释放系统对子宫内膜组织胰岛素样生长因子-1（IGF-1）的影响及预防盆腔炎疗效分析。方法：选取2010―2013年在嘉兴市妇幼保健院行宫腔镜下子宫内膜息肉切除术患者450例进行随机分组，研究组术后子宫内即时放置左炔诺孕酮宫内释放系统，而对照组不予放置。分别对术前及术后6个月子宫内膜组织IGF-1的表达情况进行对比，且随访2年，了解患者盆腔炎发生情况。结果：所有手术均成功，研究组子宫内膜组织IGF-1表达术后明显低于术前，对照组术前及术后子宫内膜组织IGF-1表达变化无差异，二组相比，术后IGF-1表达差异有显著性。随访2年对照组224例患者中39例发生盆腔炎，复发率为10.89 %，而研究组184例发生盆腔炎12例，差异有显著性；研究组子宫内膜厚度术后明显小于术前，差异有显著性，对照组子宫内膜厚度术后与术前变化无差异性。结论：左炔诺孕酮宫内释放系统对子宫内膜的IGF-1表达存在抑制作用，可能是其抑制子宫内膜增生并减少盆腔炎发生的机制之一。

关键词： 左炔诺孕酮宫内系统；胰岛素样生长因子；盆腔炎    

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为自供能传感器节点供电的最大功率点跟踪控制热能收集电路 None

Eun-Jung YOON, Jong-Tae PARK, Chong-Gun YU

《信息与电子工程前沿（英文）》 2018年 第19卷 第2期   页码 285-296 doi: 10.1631/FITEE.1601181

摘要： 提出一种简便的具有最大功率点跟踪（maximum power point tracking，MPPT）控制功能的热能收集电路，为自供能微型传感器节点供电。由于热电发生器（thermoelectric generator，TEG）的输出电压足够高，可直接驱动负载应用，故该电路免去了复杂的启动电路和直流-直流（DC-DC）升压转换器。为克服TEG设备和负载应用之间的功率失配，该电路在激活/休眠模式下工作。该热能收集电路基于0.35 μm互补式金属氧化物半导体（CMOS）工艺研制。实验结果证明该电路能正常工作，展示了MPPT方案性能。该电路实现了95.5％的峰值功效和高于99％的MPPT精度。

关键词： 热电能；能量收集；最大功率点跟踪（MPPT）控制；自供电系统；传感器节点    

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Optimal portfolio design of energy storage devices with financial and physical right market

《能源前沿（英文）》 2022年 第16卷 第1期   页码 95-104 doi: 10.1007/s11708-021-0788-2

摘要： With the continuous development of the spot market, in the multi-stage power market environment with the day-ahead market and right market, the study associated with the portfolio of energy storage devices requires that attention should be paid to transmission congestion and power congestion. To maximize the profit of energy storage and avoid the imbalance of power supply and consumption and the risk of node price fluctuation caused by transmission congestion, this paper presents a portfolio strategy of energy storage devices with financial/physical contracts. First, the concepts of financial/physical transmission rights and financial/physical storage rights are proposed. Then, the portfolio models of financial contract and physical contract are established with the conditional value-at-risk to measure the risks. Finally, the portfolio models are verified through the test data of the Pennsylvania-New Jersey-Maryland (PJM) electric power spot market, and the comparison between the risk aversion of portfolios based on financial/physical contract with the portfolio of the market without rights. The simulation results show that the portfolio models proposed in this paper can effectively avoid the risk of market price fluctuations.

关键词： portfolio     node price fluctuation     transmission right     energy storage right     risk aversion    

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Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

《医学前沿（英文）》 2018年 第12卷 第5期   页码 572-579 doi: 10.1007/s11684-017-0561-4

摘要：

The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP). This retrospective study investigated 360 women who went to urogynecological clinic for pelvic floor discomfort. Levator hiatus dimensions were obtained by three-dimensional transperineal ultrasound and results were compared between women with and without significantly objective prolapse (International Continence Society POP quantification, grade 2 or higher). Receiver operating characteristic (ROC) curve analyses were performed to determine valid screening index for detecting abnormal levator hiatus distensibility. Women with significantly objective prolapse had significantly higher levator hiatus dimensions than those without (all P <0.001). ROC curve analyses confirmed that hiatal area (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormal levator hiatus distensibility with sensitivity of 0.80 and specificity of 0.70. In this study, we used a two-step method and achieved higher sensibility (0.80 vs. 0.87) without reducing specificity (0.70 vs. 0.71) compared with a single-screening index method. As a result, we suggest that HA≥19.5 cm2 during Valsalva maneuver is an indicator of abnormal levator hiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal distensibility.

关键词： three-dimensional transperineal ultrasound     levator hiatus     levator ani muscle     pelvic organ prolapse    

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基于可观测节点信息的控制器局域网节点可靠性评估 Article

Lei-ming ZHANG, Long-hao TANG, Yong LEI

《信息与电子工程前沿（英文）》 2017年 第18卷 第5期   页码 615-626 doi: 10.1631/FITEE.1601029

摘要： 基于控制器局域网的总线技术广泛应用于网络化制造系统。网络作为系统的信息通道，其可靠性对系统的吞吐量、产品质量以及工作人员的安全至关重要。然而，由于节点内部状态的不可访问性，因此使用节点内置的错误计数器值直接评估控制器局域网节点的可靠性是难以进行的。本文提出一种新颖的控制器局域网节点可靠性评估方法，该方法使用节点脱离总线时间作为可靠性测度。基于网络错误日志和错误计数器值可访问的可观测节点信息，该方法可以估计网络中节点的发送错误计数器值。首先，本文基于分段马尔科夫链建立了估计节点发送错误计数器值的模型，该模型考虑了网络中错误分布的稀疏特性。其次，通过学习可观测节点的模型估计值和实际测量值之间的偏差，建立了贝叶斯网络以表述可观测节点的模型估计值更新机制。然后，将该更新机制应用到网络中发送错误计数器值不可访问的节点，完成其模型估计值的更新。最后，建立了节点可靠性评估方法以预测节点的脱离总线时间。为表明文中方法的有效性，进行了多组实验。实验结果表明由文中方法得到的估计值与实际观测值相一致。

关键词： 控制器局域网；发送错误计数器；发送错误计数器值估计；贝叶斯网络；脱离总线时间    

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标题 作者 时间 类型 操作

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

null

期刊论文

Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

期刊论文

The value of ultrasound elastography in differential diagnosis of superficial lymph nodes

Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,

期刊论文

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

null

期刊论文

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

期刊论文

Spatial embedded reinforcement of 20-node block element for analysis PC bridges

LONG Peiheng, DU Xianting, CHEN Weizhen

期刊论文

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

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Optimal portfolio design of energy storage devices with financial and physical right market

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Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women

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